WebJun 15, 2024 · The best OTC pain reliever for: Fever. Acetaminophen (Tylenol) is the optimal pain reliever for regulating the body temperature and relieving any aches and pains that come with a fever, says Kavita Gupta, DO, medical director of the Advocare Pain Institute of South Jersey. It is also considered the safest medication for children. WebJan 28, 2024 · It works by reducing hormones that cause inflammation and pain in the body. Ibuprofen is used to reduce fever and treat pain or inflammation caused by many conditions such as headache, toothache, …
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