WebAug 23, 2024 · Synthesis of Diarylmethanes through Palladium-Catalyzed Coupling of Benzylic Phosphates with Arylsilanes Pengbo Zhang, Jian Xu, Yuzhen Gao, Xueqin Li, Guo Tang, Yufen Zhao Chemistry Synlett 2014 Abstract An efficient approach to the benzylation of arenes has been developed. WebNov 11, 2024 · Synthesis of Indole/Benzofuran-Containing Diarylmethanes through Palladium-Catalyzed Reaction of Indolylmethyl or Benzofuranylmethyl Acetates with Boronic Acids November 2024 Synthesis 54 (03)...
Potassium‐Zincate‐Catalyzed Benzylic C−H Bond Addition of ...
WebMay 18, 2024 · Coupled with chemoselective pyridinium formation, this method allows benzyl primary amines to be efficiently converted to di (hetero)arylmethanes. Excellent heteroaryl and functional group tolerance is observed, and a one-pot procedure enables benzylic amines to be converted to diarylmethanes directly. Publication types WebDec 3, 2024 · Diarylmethane is weakly acidic [16]. These benzylic C–H bonds can be reversibly deprotonated under basic reaction conditions (MN (SiMe 3) 2, M = Li, Na, K), and the resulting carbanions act as nucleophiles in transition metal-involved [17] or transition metal-free transformations [18]. cherokee after trail of tears
Palladium-Catalysed Cross-Coupling of Benzylammonium Salts …
WebMay 18, 2024 · A nickel-catalyzed cross-coupling of benzylic pyridinium salts with arylboronic acids was developed. Coupled with chemoselective pyridinium formation, this … WebOct 6, 2015 · A practical and convenient approach for the secondary C(sp(3))-H arylation of diarylmethanes with various fluoroarenes is described. The reaction proceeds smoothly in the presence of LDA (lithium diisopropylamide) at room temperature and affords triarylmethanes in moderate to high yields. WebAug 22, 2024 · A diarylmethane such as tofogliflozin is a representative motif among multiply arylated alkanes. 1 A triarylmethane such as (+)-securidane A and a tetraarylethane such as Raptinal are also known bioactive products. 2–4 CDP-840, a phosphodiesterase (PDE)-IV inhibitor, 5 is classified as a triarylethane, and COF-102, known as a covalent organic … cherokee afghan pattern