2024 Folate receptor endocytosis and trafficking

Folate receptor endocytosis and trafficking

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WebNov 10, 2024 · The folate receptor (FR) family plays a crucial role in the uptake of folic acid, commonly known as vitamin B9, which plays a key role in the synthesis of RNA and DNA, aids epigenetic processes and is also involved in cellular proliferation and survival [1, 2].It is overexpressed on proliferating cells which require large amounts of folic acid to … WebApr 1, 2004 · Search life-sciences literature (Over 39 million articles, preprints and more)

Membrane Trafficking and Subcellular Drug Targeting …

WebAug 16, 2024 · 6.7: Receptor-mediated Endocytosis. Just as there is vesicular traffic towards the plasma membrane, either for secretion or for incorporation of membrane lipids or proteins, there can also be vesicular traffic from the plasma membrane. Endocytosis is the process by which a coat protein (usually clathrin) on the cytoplasmic side of the … WebAug 17, 2024 · Endocytosis is a fundamental mechanism by which cells perform housekeeping functions. It occurs via a variety of mechanisms and involves many … paradox unplugged spotify tab-one

A Bibliometric analysis of folate receptor research - BMC Cancer

WebJul 4, 2024 · In the present study, we developed a folate receptor-targeting i-Extract nanocomplex that possesses enhanced selective cancer cell killing activity. We provide evidence that in contrast to i-Ex, FRi-ExNC is water soluble and shows a 3-fold higher cellular uptake by FR-enriched cancer cells in vitro. WebJun 30, 2007 · Folate receptor was over-expressed to a large degree in ovarian neoplasmas that had a high histological grade, advanced stage, and serious histology. A multiple comparison analysis showed that the folate receptor expression of stage IV and omental metastases was significantly higher than that in early stage disease (5). WebOne actively pursued molecular target in EOC is folate (FR) α, a member of the folate receptor family of high affin-ity folate-binding proteins [1, 2]. FRα is a transmembrane … paradox to the moon

Membrane Trafficking and Subcellular Drug Targeting …

Dynamin-Independent Mechanisms of Endocytosis and Receptor …

WebMar 12, 2024 · Three types of folate transporters/receptors are known to exist in humans to facilitate the uptake of folate: Folate Receptors (FRs), Reduced Folate Carrier (RFC) and … WebAug 25, 2013 · The trafficking pathways taken by a recycling FR can be complex and may involve many sorting events in multiple organelles. ... Thus, caveolae-mediated endocytosis is not the only pathway for folate receptor-mediated endocytosis. Smaller NPs were internalised by ARPE-19 cells via both clathrin and caveolae-mediated pathways. paradox toothbrushWebSep 29, 2012 · Based on the natural high affinity of folate for the folate receptor, drug carriers conjugated with folate may also bind tightly to the folate receptor and trigger cellular uptake via endocytosis . As a GPI-AP, folate receptor internalization is thought to use clathrin-independent CLIC-GEEC internalization pathways [104, 145, 146]. paradox toothpaste for gum disease

"WebFolate receptor endocytosis and trafficking Shefali Sabharanjak, Satyajit Mayor* National Center for Biological Sciences, UAS-GKVK Campus, Bellary Road, Bangalore 560 065, India " - Folate receptor endocytosis and trafficking

Folate receptor endocytosis and trafficking

WebMay 8, 2013 · 4KM6, 4KM7, 4KMX, 4KMY, 4KMZ, 4KN0, 4KN1, 4KN2. PubMed Abstract: Antifolates, folate analogs that inhibit vitamin B9 (folic acid)-using cellular enzymes, have been used over several decades for the treatment of cancer and inflammatory diseases. Cellular uptake of the antifolates in clinical use occurs primarily via widely expressed … WebJun 30, 2007 · These results confirmed the PEG-folate entered into the KB cells through the folate receptor endocytosis pathway. Folic acid is taken up via the FR on the cell …

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WebMar 27, 2009 · Endocytosis – the uptake of extracellular ligands, soluble molecules, protein and lipids from the extracellular surface – is a vital process, comprising multiple mechanisms, including phagocytosis, macropinocytosis, clathrin-dependent and clathrin-independent uptake such as caveolae-mediated and non-caveolar raft-dependent … Web1 day ago · Musalli et al. [31] showed folate receptor-ligand was necessary for caveolae-mediated endocytosis. Although several studies highlighted that clathrin-mediated or caveolin-mediated endocytosis is size-dependent [32, 8], our results did not adhere to the previous findings. Rather multiple uptake mechanisms of CSRBnps were confirmed.

WebApr 29, 2004 · While folate transport into the cytoplasm is ultimately mediated by a transporter-based mechanism, membrane folate receptors (FRs) that bind folate at … WebFolic acid (FA) is crucial for fetal development. We aimed to study the modulation of FA placental uptake by: hyperserotoninemia and hyperglycaemia, anti-hypertensives, insulin and drugs of abuse.For this, we characterized 3 H-FA uptake by primary cultures of human cytotrophoblasts (TB cells) and tested the effects of these compounds upon 3 H-FA …

WebApr 29, 2004 · Folate receptor (FR) is highly expressed in many types of human cancers, and it has been actively studied for developing targeted chemotherapy and diagnostic … WebThe application of liposomal formulations as carriers for anticancer drug modified by tumor-active-targeted ligand folate has been trialed and described in the literature in recent years. 12–15 Folate conjugates can bind to the folate receptor (FR) with high affinity and enter the FR-elevated malignant cells by receptor-mediated endocytosis ...

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WebNov 16, 2024 · Background The objective of this study was to conduct a bibliometric analysis of the entire field of folate receptor research. Folate receptor is expressed on a wide variety of cancers and certain immune cells. Methods A Web of Science search was performed on folate receptor or folate binding protein (1969-to June 28, 2024). The … paradox training solutionsWebAug 5, 2024 · Endocytic trafficking relies on highly localized events in cell membranes. Endocytosis involves the gathering of protein (cargo/receptor) at distinct plasma membrane locations defined by … paradox thermal underwear merino woolWebSep 12, 2006 · Comparison of the trafficking pathways of folate-FRET reporter and transferrin (Tf) after endocytosis. Cells were treated with folate-FRET (100 nM) and Tf-Alexa 633 (5 μg/ml) for 0.5 h. paradox valley inn bed \u0026 breakfastWebDec 2, 2024 · CavME is the second most studied pathway of endocytosis and has been shown to be important in transcytotic trafficking across cells and mechanosensing. 23 The CavME process involves formation... paradox valley earthquakeWebMay 27, 2024 · The major pathways governing the trafficking of molecules such as the receptor, ligands, and solutes are known as endocytic pathways which control the … paradox vaping bournemouthWebMay 8, 2013 · Additionally, we describe the molecular details of human FR in complex with three clinically prevalent antifolates, pemetrexed (also Alimta), aminopterin, and … paradox version of suicuneWebFolate absorption is primarily mediated by a membrane transporter with micro-molar affinities for folates. Paradoxically, folates are only present at low nanomolar concentrations in extracellular milieus; membrane folate receptors (FRs) with nanomolar affinities for folates are likely to substantially modulate folate availability for these transporters. … paradox tyranitar iron thorns