2024 Fundc1 phosphorylation

Fundc1 phosphorylation

Author: crme

August undefined, 2024

WebDescription: Homo sapiens FUN14 domain containing 1 (FUNDC1), mRNA. (from RefSeq NM_173794) RefSeq Summary (NM_173794): This gene encodes a protein with a FUN14 superfamily domain. The function of the encoded protein is not known. [provided by RefSeq, Sep 2011]. Gencode Transcript: ENST00000378045.5 WebMar 26, 2014 · Mass spectrometric analysis of cellular phosphoproteome revealed that FUNDC1 has a potential phosphorylation site at Ser-17 …

Mitophagy: A novel perspective for insighting into cancer and …

WebJan 1, 2024 · Mechanically, silencing of NLRX1 further observably enhanced the relative levels of -phosphorylated FUNDC1/FUNDC1, and NLRP3 inflammasome-related proteins, while overexpression of NLRX1 exhibited inverse results in the H 2 O 2 … WebIn particular, phosphorylation of ubiquitin by PINK1 is important for triggering this pathway. Likewise, adapter proteins such as p62, optineurin (OPTN) and FUNDC1 have been identified that link ubiquitinated protein aggregates or mitochondria directly to LC3-II-studded phagophore membranes. buffy a03

Structural insights into the recognition of …

WebMar 16, 2024 · During hypoxia, FUNDC1 acts as a mitophagy receptor and accumulates at the ER (endoplasmic reticulum)-mitochondria contact sites (EMC), also called … WebJan 22, 2012 · Here we report that FUNDC1, an integral mitochondrial outer-membrane protein, is a receptor for hypoxia-induced mitophagy. FUNDC1 interacted with LC3 through its typical LC3-binding motif Y (18)xxL (21), and mutation of the LC3-interaction region impaired its interaction with LC3 and the subsequent induction of mitophagy. WebMay 10, 2024 · Moreover, blocking FUNDC1-related MAM formation with a cell-penetrating inhibitory peptide significantly suppresses the expressions of downstream angiogenic genes and inhibits tumor angiogenesis. crook ramblers

The mitophagy receptor FUN14 domain-containing 1 (FUNDC1

WebOct 5, 2024 · Similar to BNIP3 and Nix, FUNDC1 directly binds to LC3 through a conserved LIR motif in its N-terminal region to mediate mitophagy. 59 FUNDC1-mediated mitophagy is mainly regulated by phosphorylation and dephosphorylation at Ser13 and Tyr18 residues located in the LIR motif. In general, Ser13 and Tyr18 residues can be phosphorylated by … WebApr 13, 2024 · Upon dephosphorylation at Ser13, FUNDC1 becomes activated and triggers hypoxia-induced mitophagy . Defective mitophagy due to the loss of FUNDC1 results in the accumulation of swollen and abnormal mitochondria increased cytosolic mtDNA, and caspase-1 activation . In a mouse model of myocardial ischemia/reperfusion, UPRmt … crook primaryWebDec 13, 2024 · Our data suggested that FUNDC1 can be used as a prognostic biomarker in patients with cervical cancer, and may be a new therapeutic target to improve the … crook primary school term dates

"WebIn particular, phosphorylation of ubiquitin by PINK1 is important for triggering this pathway. Likewise, adapter proteins such as p62, optineurin (OPTN) and FUNDC1 have been … " - Fundc1 phosphorylation

Fundc1 phosphorylation

The mitophagy effector FUNDC1 controls ... - Science Signaling

WebInterestingly, FUNDC1 seems to play a less important role in starvation-induced mitophagy or CCCP-induced mitophagy, suggesting different mechanisms may be responsible for … WebApr 6, 2024 · Mice lacking Fundc1, a newly characterized mitophagy receptor, develop more severe obesity and insulin resistance when fed a high-fat diet (HFD). Ablation of Fundc1results in defective mitophagy and impaired mitochondrial QC in vitroand in white adipose tissue (WAT).

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WebULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy Autophagy eliminates dysfunctional mitochondria in an intricate process known as mitophagy. ULK1 is critical for the induction of autophagy, but its substrate(s) and mechanism of action in mitophagy remain unclear. WebFUNDC1 is a novel Mitochondrial-Associated-Membrane (MAM) protein required for hypoxia-induced mitochondrial fission and mitophagy. ... Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy. FEBS Lett. 2015, 8; 589(15):1847-54.

WebApr 25, 2024 · Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins Scientific Reports The mitophagy receptor Nix interacts with LC3/GABARAP proteins,... WebJan 1, 2024 · (PDF) NLRX1 increases human retinal pigment epithelial autophagy and reduces H2O2-induced oxidative stress and inflammation by suppressing FUNDC1 phosphorylation and NLRP3 activation Home Cell...

http://www.labbase.net/News/ShowNewsDetails-4-12-E0D551209ED5ABFE.html WebNov 15, 2024 · Since the phosphorylation of FUNDC1 at Ser17 by ULK1 can enhance its binding affinity to LC3B and promote mitophagic activity , we measured p (Ser17)-FUNDC1 and ULK1 levels. Our results indicated that p (Ser17) -FUNDC1 and ULK1 protein levels were significantly decreased in HL-1 cardiomyocytes in response to Ang-II stimulation, …

WebNov 22, 2024 · This work investigated the effect of thyroxine on the biogenesis and quality control system in rat heart mitochondria. In hyperthyroid rats, the concentrations of free triiodothyronine and thyroxine increased severalfold, indicating the development of hyperthyroidism in these animals. The electron microscopy showed 58% of cardiac …

Web72024 Ensembl ENSG00000069509 ENSMUSG00000025040 UniProt Q8IVP5 Q9DB70 RefSeq (mRNA) NM_173794 NM_028058 NM_001313745 NM_001313746 RefSeq … crook publishingWebJan 19, 2024 · In normal situations, FUNDC1 is phosphorylated by Src kinase and CK2. In response to hypoxia, dephosphorylation of FUNDC1 … crook primary school ofstedWebDec 17, 2024 · Under normoxic conditions, the activity of FUNDC1 is inhibited due to phosphorylation of FUNDC1 at Ser13 and Tyr18 by CK2 or Src, respectively. The phosphatase PGAM5 dephosphorylates FUNDC1 at Ser13, which is inhibited by Bcl-xL in normal conditions. In response to mitophagy stimuli, Bcl-xL is degraded and PGAM5 is … buffy7356 gmail.comWebMar 17, 2024 · During hypoxia, the interaction of FUNDC1 with LC3/GABARAP proteins is determined by the phosphorylation of Ser13, which is regulated by the interplay of a phosphoglycerate mutase (PGAM5) phosphatase and casein kinase 2 [ [ 73] ]. p62 function in autophagy is also regulated by various kinases. crook railroad tunnelWeb话说线粒体自噬，可谓是大家眼中的“老大哥”了。往期小 M 为大家介绍过自噬的分类，底物以及检测 (详见往期推文：Hello~自噬；还能这么玩儿？跟大牛解锁自噬检测)，今天小 M 带大家进一步了解线粒… buffy 7 episodiWebMar 31, 2024 · FUNDC1 is an integral molecule localized to the outer mitochondrial membrane that can interact with the LC3 protein to activate mitophagy, by altering its phosphorylation states (12). crook rd oneida wiWebReduced eNOS phosphorylation and VEGF expression, and upregulated ET-1 also suggested the endothelium dysfunction in FUNDC1 knockout mice (Fig. 1 I and J). Importantly, the EC-specific FUNDC1 deletion aggravated cardiac injury following MI/R as evidenced by reduced cardiac contractile function ( Fig. 1 K), enhanced CK-MB releases … crook primary website