WebJan 29, 2007 · Mannose receptor (MR), specifically, recognizes mannose residues on the surface of Leishmania parasites. We studied the role of MR in the pathogenesis of experimental cutaneous and visceral leishmaniasis using MR-deficient [MR-knockout (KO)] C57BL/6 mice. MR-deficient MP exhibied a comparable infection rate and cytokine … WebSome mannose residues of high-mannose type N -glycans on LEs can be phosphorylated in the Golgi apparatus through two-step enzyme reactions. The consequent M6P moiety is recognized by M6P receptors (MPRs) on the trans -Golgi network membrane and delivered through the endo-lysosomal pathway.
Mannose 6-Phosphate Receptor - an overview ScienceDirect …
WebDec 1, 2012 · Review on mannose receptor as an endocytic receptor in antigen delivery that is co-expressed with the microRNA miR-511-3p encoded within the Mrc1 gene. The MR is a highly effective endocytic receptor with a broad binding specificity encompassing ligands of microbial and endogenous origin and a poorly characterized ability to modulate … WebNov 1, 2024 · Mannose and Mannose‐6‐Phosphate Receptor–Targeted Drug Delivery Systems and Their Application in Cancer Therapy. November 2024; Advanced … islamic emirate of afghanistan leader
Mannose Receptor - an overview ScienceDirect Topics
WebApr 13, 2024 · Mannose was recently reported to halt tumor growth and impair the PPP. Mannose inhibitory effects on tumor growth are inversely related to the levels of … The mannose receptor (Cluster of Differentiation 206, CD206) is a C-type lectin primarily present on the surface of macrophages, immature dendritic cells and liver sinusoidal endothelial cells, but is also expressed on the surface of skin cells such as human dermal fibroblasts and keratinocytes. It … See more Domain organisation The mannose receptor is a type I transmembrane protein, with an extracellular N-terminus and an intracellular C-terminus. It is first synthesised as an inactive precursor, … See more The selective internalisation properties of the mannose receptor indicate a number of potential applications in health and disease. By manipulating the glycosylation of important bioactive proteins to a highly mannosylated state, their serum levels could be tightly … See more Phagocytosis of pathogens A number of pathogenic microorganisms, including C. albicans, Pneumocystis carinii and Leishmania donovani display glycans on their surfaces with terminal mannose residues that are recognised by the C-type CRDs of the … See more • mannose+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • Macrophage Mannose Receptor See more WebJan 1, 2024 · The mannose receptor is a prototype for a family of proteins that have similar domain organization. The other three members of the family are Endo180, also known as urokinase plasminogen activator receptor-associated protein or uPARAP, the phospholipase A 2 receptor, and DEC-205 ( 21 ). key lime cookie cups