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Shoc2 uniprot

WebRegulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. This gene encodes a protein that consists … Web4 May 2024 · To study SHOC2 function in adult tissue homeostasis, SHOC2 KO and KI mice were crossed with animals carrying an inducible ubiquitously expressed CreERT2 recombinase (R26-CreERT2). Treatment with tamoxifen leads to efficient recombination (>80%) in all tissues examined except brain. Significantly, SHOC2 inactivation is tolerated …

Q9UQ13 SWISS-MODEL Repository

WebResearch studies have demonstrated that SHOC2 forms a complex with the catalytic subunit of the PP1 phosphatase and M-Ras, and this complex drives activation of Raf-ERK signaling in response to mitogenic growth factors (1). SHOC2 has also been shown to cross-talk with and activate the PI3K/Akt signaling axis through its interaction with the ... Web29 Sep 2024 · SHOC2 is as an essential scaffolding protein that engages both PP1C and RAS to dephosphorylate RAF NTpS 11-13 , but the structure of SHOC2 and the … hobbies to find yourself https://gtosoup.com

SHOC2 - My Cancer Genome

Web5 Nov 2024 · Studies over the past decade have uncovered the critical role of the Shoc2 scaffold in the transmission of signals through the core ERK1/2 cascade (Jang et al., 2024).These studies convincingly demonstrated that this seemingly auxiliary component of the ERK1/2 signaling network is an indispensable regulator of the ERK1/2 pathway, as its … UniProt is a GBC global core biodata resource Main funding by: National Institutes of Health We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2024. See more This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. 1. Name1 2. See … See more WebFull gene name according to HGNC. SHOC2 leucine rich repeat scaffold protein. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to … hrst inc mn

Structure of the MRAS–SHOC2–PP1C phosphatase complex

Category:Structure of the SHOC2–MRAS–PP1C complex provides ... - bioRxiv

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Shoc2 uniprot

UniProt

WebKIAA0862. Sequence Length (AA) Molecular Weight (Da) 582. 64888. Protein Name. Leucine-rich repeat protein SHOC-2. Sources. UniProt. Web15 Apr 2024 · The SHOC2-MRAS-PP1C holophosphatase complex functions as a key regulator of RTK-RAS signalling by removing an inhibitory phosphorylation event on the …

Shoc2 uniprot

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WebMolecularly, SHOC2 is a scaffold protein that brings together activated Ras (activated via G-protein coupled receptors and the interaction of GTP to GDP) and Raf, which then facilitates the transfer of the phospho-Raf phosphate to other proteins for the activation of the MAP Kinase pathway for gene activation. WebSubcellular - SHOC2 - The Human Protein Atlas SUMMARY TISSUE BRAIN SINGLE CELL TISSUE CELL PATHOLOGY DISEASE IMMUNE BLOOD SUBCELL CELL LINE SHOC2 SUBCELLULAR RNA EXPRESSION HUMAN CELLS MOUSE CELLS ANTIBODIES AND VALIDATION Dictionary Cytosol Nucleoplasm Subcellular proteome Cytosol Nucleoplasm

WebExpression of SHOC2 in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Web1 Apr 2006 · Shoc2 function is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of Shoc2 expression inhibits MAPK, but not PI3K activity. We propose that the Shoc2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Full text links

Web4 Feb 2024 · SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and …

Web13 Jul 2024 · A structure of the MRAS–SHOC2–PP1C complex supports a RAS-driven and multi-molecular model for RAF activation in which individual RAS–GTP molecules recruit RAF–14-3-3 and SHOC2–PP1C to ...

Web Transcripts that don't contain an open reading frame (ORF) and cannot be placed in one of the other categories. hrst knotsWeb13 Jul 2024 · SHOC2 forms a ternary complex with MRAS and PP1C, and human germline gain-of-function mutations in this complex result in congenital RASopathy syndromes 2, 3, 4, 5. However, the structure and... hrs titleWebSoc-2 suppressor of clear homolog (SHOC2) is a gene that encodes a protein that functions in the RAS/ERK MAP kinase signaling pathway as a scaffold linking Ras to downstream … hrst in paWebUniProt is a GBC global core biodata resource Main funding by: National Institutes of Health We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s … hobbies to gain humilityWebSHOC2 localizes to cytoplasm when inactive but rapidly translocates to the nucleus when activated, such as during growth factor stimulation. Thus, as expected, SHOC2 also participates in FGF receptor signaling. ... Uniprot describes 2 isoforms at ~60 kDa and ~65 kDa Uncharacterized bands may appear in some lysate(s). hobbies to get into after collegeWeb10 Jun 2024 · SHOC2 inhibition perturbs tumour growth in lung cancer models. To study the in vivo role of SHOC2 we have developed two mouse models of SHOC2 inactivation using Knock-out (KO) or Knock-in (KI ... hobbies to get away from gamingWebWelcome to ProteomicsDB! ProteomicsDB is an effort of the Technische Universität München (TUM). It is dedicated to expedite the identification of the human proteome and its use across the scientific community. hrs tm31