WebMay 25, 2024 · Here we report the cryo-electron microscopy structures of human, bovine and rat NTCPs in the apo state, which reveal the presence of a tunnel across the membrane and a possible transport route for the substrate. Moreover, the cryo-electron microscopy structure of human NTCP in the presence of the myristoylated preS1 domain of LHBs, … WebUnlocking the secrets to human NTCP structure. Article. Full-text available. Aug 2024; Xiangbing Qi; Wenhui Li; View. Entry of hepatitis B virus: going beyond NTCP to the nucleus. Article. Oct 2024;
Unlocking the secrets to human NTCP structure - cell.com
WebJun 20, 2024 · c Cryo-EM map of human wild-type NTCP bound to NTCP_Fab12, a Fab-binding nanobody, and substrates. d Ribbon diagram of NTCP, with bound Na + ions shown as purple spheres. WebAug 1, 2024 · Ten years after our initial reports, four recent studies separately resolved the cryo-EM structure of human NTCP under different states and conditions [37][38][39][40] … graystillplays youtube.fandom.com
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WebMay 18, 2024 · Structure of thermostabilised human NTCP in complex with nanobody 87. The liver takes up bile salts from blood to generate bile, enabling absorption of lipophilic nutrients and excretion of metabolites and drugs 1 .Human Na + -taurocholate co-transporting polypeptide (NTCP) is the main bile salt uptake system in liver.NTCP is also … WebUnlocking the secrets to human NTCP structure ... Terms and Conditions. The cryoelectron microscopy structures of NTCP (PDB: 7PQG and 7PQQ). Note: NTCP residue 86 lysine was mutated to asparagine in the structural study. ... WebAug 1, 2024 · Unlocking the secrets to human NTCP structure. Sodium taurocholate co-transporting polypeptide (NTCP) is encoded by the solute carrier family 10 member 1 … graystillplays youtube hurricane